The best Side of bosentan venta

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Bosentan is demonstrated to generally be teratogenic in rats at plasma ranges increased than one.5 moments the plasma concentrations realized at the therapeutic dose in people. Teratogenic outcomes, together with malformations of the head and experience and of the foremost vessels, had been dose dependent.

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Se metaboliza principalmente por el sistema hepático a través de la vía encimática del citocroma P450 y se elimina por excreción biliar. Bosentan es un inductor enzimático de las isoenzimas 3A4 y 2C9 del citocroma P450. Posee un perfil farmacocinético único con una vida media de eliminación de aproximadamente 5 horas, aunque sus concentraciones estacionarias no se alcanzan hasta 3–five días como resultado de un aumento en el aclaramiento de la droga y autoinducción luego de dosificarse en multiples dosis diarias. Los efectos adversos de mayor riesgo lo son el potencial para producir defectos congénitos y hepatotoxicidad.

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